Tretinoin and arsenic drugs for newly diagnosed acute promyelocytic leukemia
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial studies how well a combination of tretinoin (ATRA) and arsenic trioxide (ATO)—with or without another antibody-like drug called gemtuzumab—treats people with newly diagnosed acute promyelocytic leukemia (APL). The goal is to see if these medicines work better together and are safe.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your leukemia diagnosis must be confirmed as APL using a specific gene test (PML-RAR-alpha fusion)
- You must be able to read, understand, and sign consent to join a research study
- If you already started urgent APL treatment (ATRA, ATO, and/or one dose of idarubicin), you may still be eligible
- If you can become pregnant, you must have a negative pregnancy blood test at screening and again within 48 hours before starting study drugs
- You must agree to use two reliable birth-control methods during the study if you are sexually active and pregnancy is possible
- Before starting, your heart rhythm test (EKG) must not show a QTcF value above 480 milliseconds
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether an oral version of arsenic trioxide works as well as the IV version for people with a certain type of leukemia called APL. It aims to confirm that taking the drug by mouth has similar safety and effectiveness.
This trial tests a new drug, QTX-2101, in people with acute promyelocytic leukemia (APL) that is low- or intermediate-risk. The study aims to see if the drug works and is safe for those who qualify.
This trial tests a new drug called APG1252 combined with azacitidine (AZA) for people with high-risk AML or certain related blood cancers. The goal is to see if the combination works better than standard treatments.
This trial tests a combination of oral arsenic and ATRA for people newly diagnosed with acute promyelocytic leukemia (APL). It aims to see if this drug combo can treat the disease effectively without standard chemotherapy.
This trial tests if combining interferon-α with arsenic trioxide (ATO) can help people whose acute promyelocytic leukemia (APL) has stopped responding to arsenic treatment. If you have this type of leukemia that came back or didn't get better after arsenic therapy, this study may offer a new option.
This Phase 2 study tests a treatment approach for children and teens newly diagnosed with acute promyelocytic leukemia (APL) that is confirmed by a specific lab genetic change. It may help improve outcomes, but it requires meeting several safety and test-confirmation criteria.
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