Simvastatin to protect the heart during heart surgery
Treatments studied
Part of Genetic & congenital, Heart & circulation clinical trials.
This trial looks at whether simvastatin (a cholesterol medicine) can help protect the heart during cardiac surgery. You might be invited if you’re having surgery for certain, non-complex heart conditions, but not if you have some specific related health problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be older than 18 years
- Have non-complex congenital (since-birth) heart disease
- Have isolated heart valve disease (valve problem only)
- Do not have coronary artery disease (blocked heart blood vessels)
- No known allergy to statins, including simvastatin
- You should not have poor liver function or hepatitis; also, you cannot be pregnant or breastfeeding
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether taking a cholesterol-lowering medicine (a statin) after certain aortic surgeries can reduce harmful changes in the heart and other organs. You might benefit by lowering the risk of ongoing damage after your acute aortic condition and surgery.
This trial studies whether taking atorvastatin (a cholesterol medicine) around the time of surgical aortic valve replacement can improve outcomes. It is mainly for people who have not taken similar medicines recently and do not have certain heart rhythm or liver/kidney problems.
This study looks at whether taking statin medicines around the time of surgical aortic valve replacement can lower the chance of a common post-surgery heart rhythm problem called atrial fibrillation. It also compares statin-related factors in people who are at the time of surgery in normal rhythm and not on strong rhythm-stabilizing medicines.
This trial tests whether adding a common cholesterol-lowering drug (a statin) to standard chemotherapy before surgery can improve outcomes for people with esophageal or gastroesophageal junction cancer. The goal is to see if the statin helps shrink the tumor and reduces the chance of the cancer coming back.
This study tests whether a personalized treatment approach can improve heart function in people with dilated cardiomyopathy (a condition where the heart becomes enlarged and weak). It focuses on patients who still have low heart function despite standard medications.
This trial tests how certain statin drugs (medicines that lower cholesterol) affect heart and blood vessel function in healthy people. If you are healthy, you may help researchers understand how these drugs work.
Hear when a new Congenital Heart Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.