Atorvastatin during heart valve surgery for patients over 60
Treatments studied
Part of Heart & circulation clinical trials.
This trial studies whether taking atorvastatin (a cholesterol medicine) around the time of surgical aortic valve replacement can improve outcomes. It is mainly for people who have not taken similar medicines recently and do not have certain heart rhythm or liver/kidney problems.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are having planned (elective) single aortic valve replacement surgery using a bioprosthetic valve
- Your heart rhythm is normal (sinus rhythm), and you are not on anti-arrhythmia medicines besides beta-blockers
- You have not taken statins (cholesterol-lowering medicines like atorvastatin) in the last 3 months
- You are over 60 years old and willing to sign consent to be randomly assigned to treatment
- You do not have a history of atrial fibrillation or any prior heart surgery
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether taking statin medicines around the time of surgical aortic valve replacement can lower the chance of a common post-surgery heart rhythm problem called atrial fibrillation. It also compares statin-related factors in people who are at the time of surgery in normal rhythm and not on strong rhythm-stabilizing medicines.
This trial tests whether taking a statin before and after lung surgery can prevent a common heart rhythm problem called atrial fibrillation (AFib). If you are 60 or older and having a lung segment or lobe removed, this study may help you avoid AFib after your operation.
This Phase 3 study tests whether taking atorvastatin (a cholesterol-lowering medicine) can improve outcomes for women with estrogen-receptor–positive breast cancer. It may help by affecting cancer-related pathways and reducing risk of recurrence or progression.
This trial tests whether giving a high dose of a statin (atorvastatin) before and during a heart valve replacement procedure (TAVR) can reduce the risk of brain injury. Statins are cholesterol-lowering drugs that may also protect the brain, and this study aims to see if they help people undergoing TAVR.
This trial tests whether taking a cholesterol-lowering medicine (a statin) after certain aortic surgeries can reduce harmful changes in the heart and other organs. You might benefit by lowering the risk of ongoing damage after your acute aortic condition and surgery.
This trial looks at whether simvastatin (a cholesterol medicine) can help protect the heart during cardiac surgery. You might be invited if you’re having surgery for certain, non-complex heart conditions, but not if you have some specific related health problems.
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