Stem cell transplant chemotherapy for Fanconi anemia
Treatments studied
Part of Blood & lymphatic, Cancer, Genetic & congenital, Hormones & metabolism clinical trials.
This Phase 2 study tests a stem cell transplant approach using adjusted chemotherapy doses for people with Fanconi anemia. It may help replace damaged bone marrow and treat blood problems like severe aplastic anemia, MDS, or leukemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You (the patient) have Fanconi anemia.
- Your current blood condition is one of these: severe aplastic anemia, MDS, or acute myeloid leukemia (AML) (with rules about disease status).
- You will have a stem cell donor who is either a close match from a matched related person or a matched unrelated person (not a fully matched sibling).
- You can physically handle treatment (your heart, liver, kidneys, and lungs tests must meet study thresholds).
- You and your donor agree to take part by signing consent, and you must not be pregnant or breastfeeding during the study; women must be willing to do a pregnancy test and avoid pregnancy.
- You do not have certain problems that would block participation, such as active infections that are not controlled, active leukemia in the brain/CNS, or HIV or HTLV infection.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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