Lower blood pressure to protect the brain in older adults
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests whether better blood pressure control can slow changes seen on brain scans in older people. It focuses on people with high blood pressure and “wear-and-tear” type brain lesions on MRI.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 60 to 88 years old
- You have a memory/thinking concern and a recent MMSE score of 20 or higher (done within 6 months)
- Your MRI (or older scan) shows moderate-to-severe brain white-matter changes
- You have high blood pressure (top 140 or bottom 90, either treated or untreated)
- Your doctor has ruled out certain safety issues for MRI (like metal in the body or a pacemaker)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study watches how small blood vessels in the brain change over time. It may help doctors understand brain health as people age.
This study looks at how well the brain's blood vessels work in midlife. It involves two visits to the University of Pittsburgh and includes an MRI and a mental math test.
This trial looks at how to slow cognitive decline and early dementia in people with a specific kind of “silent” blood vessel damage in the brain seen on scans. It may help identify whether targeting this hidden condition can protect thinking and memory over time.
This study looks at how the brain's blood vessels respond to changes in blood flow in healthy younger adults. It helps researchers understand normal brain aging.
This study looks at how blood flow in the brain and related brain processes change after stroke, especially when someone also has conditions like dementia, depression, or delirium. It may help researchers understand what drives these problems and how they connect.
This study tests whether setting a lower blood pressure goal can help prevent future memory and thinking problems in older adults. It compares a more intensive blood pressure plan with usual care to see if it better protects the brain over time.
Hear when a new Cerebrovascular Disorders trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.