Stem cell transplant for primary immune system disorders
Treatments studied
Part of Blood & lymphatic, Immune system & allergy, Infections clinical trials.
This study tests whether an allogeneic stem cell (bone marrow) transplant can correct an inherited immune problem in people with severe primary immunodeficiencies. It may help reduce life-threatening infections and improve quality of life, depending on your overall health and donor match.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 4 to 75 (including children).
- You have a confirmed immune problem (often a known genetic mutation) or a doctor determines your immune disorder is severe enough to consider transplant.
- Your past medical history includes at least two major signs of severe immune disease, such as serious infections, unusual germs, repeated antibiotics, chronic virus activity, or immune over-reactions/autoimmune problems.
- A donor is available: a closely matched related or unrelated donor (not an identical twin) OR a half-match related donor.
- You can safely tolerate transplant: heart, lung, liver, and kidney tests are within required ranges, and you are well enough to do the study (performance status).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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