Testing IV diuretic treatment for sudden worsening heart failure
Part of Heart & circulation, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial studies how an IV (into-the-vein) “water pill” (furosemide/loop diuretic) works in people whose heart failure has suddenly gotten worse. It may help doctors find the best way to reduce fluid-related symptoms like breathing trouble and swelling.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are over 18 years old
- Your heart failure recently worsened suddenly, causing symptoms like shortness of breath, needing extra pillows to breathe, swelling, or major fatigue
- You have supportive signs of fluid overload (for example, lung crackles, swollen liver, fluid seen on a chest X-ray, bulging neck veins, or a third heart sound)
- Your blood test shows BNP over 100 pg/mL
- You can’t have had more than 40 mg of IV furosemide before starting (in the way the trial defines)
- You are not on kidney replacement and do not have severe kidney failure (end-stage kidney disease); also no very low blood pressure (systolic under 80), very high creatinine, or a recent heart attack
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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