Acetazolamide and Furosemide for Acute Heart Failure
Part of Heart & circulation clinical trials.
This trial tests whether adding an oral water pill (acetazolamide) to standard IV furosemide helps people with acute heart failure who have fluid overload. It aims to see if the combination improves outcomes better than furosemide alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have acute heart failure with signs of fluid overload (swelling, fluid in belly, or lungs).
- You are already taking at least 40 mg of furosemide (water pill) daily for at least a month.
- Your NT-proBNP level (a heart stress marker) is high (over 300 pg/mL or age-adjusted).
- You do not have a recent heart attack or unstable angina.
- Your kidney function is not very low (eGFR above 20).
- You are not pregnant, breastfeeding, or on dialysis.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study tests whether adding acetazolamide or metolazone to standard treatment helps remove extra fluid better in people hospitalized for heart failure. It aims to find a safer and more effective option for managing fluid overload.
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This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
This trial compares two different water pills (acetazolamide and metolazone) added to standard treatment to help remove excess fluid in people hospitalized with acute heart failure. The goal is to find which works better to ease symptoms and improve recovery.
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This trial tests different water pill (diuretic) strategies for people hospitalized with acute heart failure and too much fluid. It is designed for patients who may not respond well to standard water pills, to find a more effective way to relieve symptoms.
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