Biopsy study to test skin inflammation gene signals
Part of Blood & lymphatic, Brain & nervous system, Heart & circulation, Immune system & allergy, Lungs & breathing, Skin clinical trials.
This study uses a skin biopsy to look at “gene signals” (transcriptomics) in patients with active vasculitis that shows up on the skin. It may help researchers understand what is happening in your disease and how different types of vasculitis differ.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have an active skin lesion that your doctor thinks is from vasculitis (for example purplish spots, raised/palpable bruiselike areas, nodules, ulcers, or painful hive-like patches).
- Your vasculitis is one of these types: cryoglobulinemic vasculitis, drug-induced vasculitis, EGPA, IgA vasculitis, isolated cutaneous vasculitis, GPA, microscopic polyangiitis, PAN, or urticarial vasculitis.
- You are willing and able to sign written consent (or have a legal guardian provide consent if needed).
- You can safely have a skin biopsy—your doctor does not think the biopsy risk is too high for you (like infection/bleeding risk).
- Your blood counts are high enough: neutrophils 1500/mm³ or more, platelets 50,000/mm³ or more, and hemoglobin 7 g/dL or more.
- You are not pregnant or nursing, and you do not have an active infection near where the biopsy would be taken.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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