Testing ATO plus ATRA for NPM1-mutated AML after remission
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial studies whether a combination medicine (ATO plus ATRA) is safe and works better in people with a specific type of AML (acute myeloid leukemia) caused by an NPM1 mutation. You would join only after your leukemia has reached remission, meaning the active leukemia has cleared after initial treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 14 and 55 years old
- Your AML test shows an NPM1 mutation (and it is not a rare APL subtype)
- Your leukemia is currently in remission after your first (induction) treatment
- You can travel through study visits and are medically stable (heart, liver, and kidney tests must be acceptable)
- Your performance/energy level is not too limited (ECOG score 2 or less)
- You must not be pregnant or breastfeeding, and you must be able to follow the study plan
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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