Cell therapy for relapsed or refractory AML with NPM1 mutation
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new type of cell therapy, called MB-dNPM1-TCR.1, for people with acute myeloid leukemia (AML) that has returned or not responded to standard treatments. The therapy uses your own immune cells, which are specially trained to find and attack leukemia cells that have a specific mutation in the NPM1 gene.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be 18 years or older.
- Your leukemia (AML) has come back or hasn't gotten better after at least two rounds of standard treatment.
- You must have a specific blood marker called HLA-A*02:01.
- Your leukemia cells must have a mutation in the NPM1 gene.
- You need to have a white blood cell count of at least 1000, with less than half of those cells being leukemia cells.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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