Revumenib with 7+3 and midostaurin for AML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This trial tests a new drug called revumenib combined with a strong chemotherapy regimen (7+3) and midostaurin for people with newly diagnosed AML that has specific gene mutations (FLT3 and NPM1). The goal is to see if this combination works better than standard treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a type of AML with both a FLT3 and an NPM1 gene change.
- You need to be newly diagnosed and between 18 and 74 years old.
- Your heart, kidneys, and liver must be working well enough for strong chemotherapy.
- You should be in good enough shape to do daily activities (like walking or light work).
- You cannot have certain other health problems, like HIV, uncontrolled infections, or a history of other cancers that came back.
- You must be able to swallow pills and avoid grapefruit and certain medications during the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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