Study of heart failure with preserved pumping function
Part of Heart & circulation clinical trials.
This study looks at people who have heart failure symptoms but whose heart pumping strength is not reduced. Researchers aim to better understand this type of heart failure and compare it with people who have no history of heart disease or heart failure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have heart failure symptoms that fit a standard heart-failure severity level of class II or higher (or you were hospitalized for heart failure within the last 12 months).
- Your blood test shows elevated NT-proBNP (greater than 350 pg/mL).
- Your heart ultrasound/evaluation fits heart failure rules: pumping strength is usually 50% or higher (or 40% or lower if your type is different).
- Tests show signs your heart has trouble relaxing (diastolic dysfunction) as judged by heart imaging measurements (for example, LA size and E/e’).
- You do NOT have major excluded conditions such as severe heart valve disease, recent heart attack/acute coronary syndrome within 30 days, or chronic severe lung disease (COPD GOLD 3–4).
- You do NOT have excluded conditions like atrial fibrillation with very fast heart rate, very low hemoglobin (severe anemia), end-stage kidney failure needing dialysis, significant liver dysfunction, or an active/evolving cancer.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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