Brain stimulation for stubborn depression: intensity study
Part of Mental health clinical trials.
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have a current diagnosis of major depression (major depressive disorder).
- You have tried at least two different antidepressant treatments that did not work well enough.
- You are on a stable dose of your current depression medicine for at least 4 weeks.
- You do not have a metal implant, pacemaker, or other device that would prevent MRI or TMS.
- You are not pregnant and do not have a history of bipolar disorder, schizophrenia, or a recent substance use problem.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether a type of brain stimulation called iTBS can improve depression and thinking skills. It uses a magnetic coil over the scalp and is done on multiple days.
This study tests a type of brain stimulation called theta burst stimulation (TBS) for depression. It uses advanced imaging to see how the brain responds, which may help tailor treatment.
This study is testing whether a new type of brain stimulation called intermittent theta burst stimulation (iTBS) can help people with treatment-resistant depression (depression that hasn't improved with standard medicines). It also looks at certain blood markers to see if they can predict how well someone will respond to this treatment.
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
This trial tests a faster version of a brain stimulation treatment called intermittent theta-burst stimulation (iTBS) for teenagers with depression. The treatment uses magnetic pulses to stimulate the brain and may help improve mood when medication alone isn't enough.
Hear when a new Depression, Unipolar trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.