Doxycycline added to a chest drain for cancer fluid buildup
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial studies whether adding an antibiotic called doxycycline to an indwelling chest drain improves symptoms and fluid control in people with cancer-related fluid around the lungs. It’s mainly for patients who are getting this drain placed and can complete brief symptom check-in questions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cancer fluid around the lung (malignant pleural effusion) and are getting a drainage catheter placed
- You can understand the study, consent, and answer symptom questions by phone or in clinic
- If you’re an inpatient, you’re expected to go home within 5 days after the catheter is placed
- You are not pregnant
- You have not already had the same-side “inside-the-chest” treatment with doxycycline or similar medicine before
- Your doctor says doxycycline is safe for you (no allergy) and your fluid buildup isn’t in a pattern that blocks treatment
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies specific markers (biomarkers) found in fluid from a chest drain to better understand pleural effusions (fluid around the lungs), especially when fluid keeps coming back after treatment. You may be helped by contributing to research that could improve how these effusions are diagnosed and managed.
This trial tests a new drug called JMKX000197 against a standard chemotherapy drug (cisplatin) to see which is better at reducing fluid buildup around the lungs in people with advanced cancer. The goal is to ease breathing and improve quality of life.
This study compares two ways to stop fluid from building up again in the chest for people with cancer-related fluid buildup. One method uses a medicine called bleomycin, and the other uses a physical rubbing procedure during a scope exam. The goal is to help you breathe easier and improve your quality of life.
This trial compares two ways to drain fluid that has built up around the lungs (pleural effusion) when it is not caused by injury. One method uses a thin, flexible tube (pigtail catheter), and the other uses a larger chest tube. The goal is to see which method works better and is more comfortable for patients.
This trial studies a procedure called pleurodesis, which helps stop fluid from building up around the lungs. It uses a small tube to deliver a substance that sticks the lung to the chest wall, which may reduce the need for repeated drainage in people with fluid caused by conditions like cancer.
This trial tests a new drug given directly into the chest cavity to treat fluid buildup caused by non-small cell lung cancer. It may help ease breathing problems and control the fluid.
Hear when a new Pleural Neoplasm trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.