Treatment
Doxycycline clinical trials
We’re tracking 36 recruiting studies that include Doxycycline, each written for real people, not researchers, below.
Recruiting studies
- NCT07488949Recruiting
Doxycycline and progestin for chronic endometritis in recurrent pregnancy loss
This trial tests whether combining an antibiotic (doxycycline) with a hormone treatment (progestin) can help people with chronic endometritis—a type of uterine inflammation—who have had repeated miscarriages or failed IVF cycles. The goal is to improve the chance of a successful pregnancy.
Lanzhou, GansuAges 20–45 - NCT07180563RecruitingPhase 1/Phase 2
Berberine and doxycycline for chronic endometritis
This trial tests if adding berberine (a plant compound) to the antibiotic doxycycline works better than doxycycline alone for treating chronic endometritis, a long-term inflammation of the womb lining that can affect fertility. It may help women who have this condition.
Yiwu, ZhejiangAges 20 years+ - NCT06738407RecruitingPhase 4
Doxycycline to prevent STIs in high-risk people
This study tests whether taking a daily antibiotic (doxycycline) can prevent sexually transmitted infections in people at high risk. If you've had an STI recently and sometimes have sex without condoms, you might be able to join.
Los Angeles, CaliforniaAges 13–29 - NCT03337932Recruiting
Shorter doxycycline course for multiple early Lyme skin rashes
This study looks at how long to take doxycycline for people who have multiple early Lyme disease skin rashes. It may help find the shortest effective treatment duration while keeping side effects low.
LjubljanaAges 18 years+ - NCT05112211Recruiting
Imaging study of doxycycline in thyroid eye disease
This study looks at how doxycycline (an antibiotic) affects thyroid eye disease using special imaging pictures. It may help doctors better understand disease activity and how well treatments work.
Guangzhou, GuangdongAges 18–70 - NCT04762134Recruiting
Doxycycline to prevent future bacterial STIs in high-risk men
This trial tests whether taking doxycycline can lower the chance of getting bacterial sexually transmitted infections like syphilis, gonorrhea, and chlamydia. It is aimed at men who have had these infections recently and expect to keep having multiple male partners.
Calgary, AlbertaAges 18 years+ - NCT07544251RecruitingPhase 4
Sarecycline vs. Doxycycline for Acne and Gut Health
This study compares two antibiotic medications (sarecycline and doxycycline) to see which one works better for moderate acne while also being gentler on the bacteria in your gut. Researchers will track how your skin improves and how these drugs affect your digestive system.
Sacramento, CaliforniaAges 9 years+ - NCT05874570RecruitingPhase 4
Doxycycline for H. pylori after prior treatment failure
This trial tests whether doxycycline can “rescue” or improve treatment for an H. pylori infection that has already not responded to previous therapy. It may help people whose stomach infection keeps coming back or never cleared.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT07500415Recruiting
Doxycycline to prevent STIs in Rio de Janeiro
This trial tests whether taking the antibiotic doxycycline can prevent sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in people at higher risk. If you are a man or transgender woman who has sex with men, are living with HIV or on PrEP, and have had an STI in the past year, you may be able to join.
Rio de Janeiro, Rio de JaneiroAges 18 years+ - NCT07498010RecruitingPhase 2
Doxycycline for post-surgery fluid pockets
This trial tests if doxycycline, an antibiotic, can help treat fluid pockets (seromas) that form after orthopedic surgery. It may reduce the need for drainage or additional procedures.
Coral Gables, FloridaAges 18 years+ - NCT07397403RecruitingPhase 4
Doxycycline to prevent STIs in men who have sex with men
This trial tests whether taking a single dose of doxycycline after sex can prevent common sexually transmitted infections (STIs) like gonorrhea, chlamydia, and syphilis in men who have sex with men (MSM) in Bangkok.
Sathorn, BangkokAges 3 weeks–2 months - NCT07343635Recruiting
Anti-inflammatory therapy with yellow light for rosacea
This trial tests a combination of an anti-inflammatory gel (Hirudoid), yellow light therapy, and two oral medications (tofacitinib and doxycycline) for Chinese adults with mild to moderate rosacea that causes redness and visible blood vessels. The goal is to see if this approach reduces symptoms safely.
Yiwu, ZhejiangAges 18–70 - NCT06477185RecruitingPhase 2
Preventing lung scarring after TB with doxycycline
This trial tests whether the antibiotic doxycycline can prevent lung scarring (fibrosis) after a serious TB infection. You may be eligible if you are currently being treated for active TB and have significant lung damage on your chest X-ray.
Kampala, KampalaAges 18–65 - NCT07164131RecruitingPhase 4
Comparing two antibiotics for hospitalized pneumonia patients
This trial compares two antibiotics, azithromycin and doxycycline, when given alongside a standard beta-lactam antibiotic to hospitalized adults with community-acquired pneumonia. It aims to see which combination works better and is safer.
Scottsdale, ArizonaAges 18 years+ - NCT06683638RecruitingPhase 2
Daily doxycycline for early syphilis treatment
This trial tests if taking a daily antibiotic (doxycycline) for two weeks can treat early syphilis in adults. It may help people who have been diagnosed with primary, secondary, or early latent syphilis.
Seattle, WashingtonAges 18 years+ - NCT06446245RecruitingPhase 2
Doxycycline for brain tuberculosis
This trial tests whether adding the antibiotic doxycycline to standard treatment can improve recovery in patients with tuberculosis of the brain (TB meningitis). It may help reduce brain swelling and damage.
Medan, MedanAges 21 years+ - NCT06452394RecruitingPhase 2
Testing doxycycline with chemo for breast cancer
This trial tests whether adding the antibiotic doxycycline to standard chemotherapy before surgery can better target breast cancer stem cells in people with ER-positive, HER2-negative breast cancer. The goal is to improve treatment response.
Sankt Gallen, Canton of St. GallenAges 18 years+ - NCT06069141Recruiting
Comparing syphilis treatments for people with HIV
This study compares the standard treatment for early syphilis with a combination that includes an extra antibiotic, to see which is more effective. It is for people living with HIV who have early syphilis.
Hsinchu, TaiwanAges 18 years+ - NCT05473520RecruitingPhase 3
Doxycycline add-on therapy for lung improvement in tuberculosis
This Phase 3 trial tests whether adding doxycycline to standard TB medicine can improve lung function and reduce lung tissue damage. It aims to see if patients recover better by targeting the lung response to TB.
Kota Kinabalu, SabahAges 21 years+ - NCT03465774Recruiting
Doxycycline added to a chest drain for cancer fluid buildup
This trial studies whether adding an antibiotic called doxycycline to an indwelling chest drain improves symptoms and fluid control in people with cancer-related fluid around the lungs. It’s mainly for patients who are getting this drain placed and can complete brief symptom check-in questions.
Houston, TexasAges 18 years+ - NCT04723940Enrolling by invitationPhase 3
Oral vs intravenous antibiotics for joint infection
This trial compares taking antibiotics by mouth versus through an IV line for people who have an infection in their hip or knee replacement. The goal is to see if oral antibiotics work just as well as IV antibiotics after surgery to clean the infection.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07755618Enrolling by invitationPhase 1
Doxycycline levels and adherence study
This study looks at how the antibiotic doxycycline stays in your body and how well people stick to taking it. It may help find better ways to prevent infections.
Chapel Hill, North CarolinaAges 18–65 - NCT06809829Recruiting
Doxycycline gel sponge for front tooth implants
This trial tests whether a special sponge containing doxycycline (a type of antibiotic) placed around a new implant in the front of the mouth helps it heal better. It's for people who need a single tooth replaced in the upper front area.
Kafrelsheikh, KafrelsheikhAges 18–50 - NCT05268120Recruiting
Treatment to clear MRSA in people with difficult carriage
This study tests ways to get rid of MRSA bacteria in the body when it is “complicated,” such as having MRSA outside the nose or an ongoing MRSA infection. It may help reduce future MRSA problems or infections by lowering how long the bacteria stay in your body.
LeidenAges 18 years+
What Doxycycline is being studied for
Conditions with recruiting Doxycycline studies.
Common questions
- Are there clinical trials studying Doxycycline?
- Yes. Clin2 currently lists 36 recruiting studies that include Doxycycline, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Doxycycline trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Doxycycline an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Doxycycline or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.