Alfapump device to reduce stubborn belly fluid in liver disease
Part of Digestive system clinical trials.
This study looks at whether placing an Alfapump under the skin can better manage “refractory ascites,” which is stubborn belly fluid buildup in people with cirrhosis. It also evaluates the medical and economic impact of this care, and who benefits most.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have cirrhosis-related belly fluid that keeps coming back (you needed at least 5 fluid drain procedures in the last 3 months).
- Your doctor expects you may live at least 6 more months.
- You cannot safely get TIPS (a shunt procedure) or you do not want it, or a previous TIPS is not working.
- You are covered by social security and can sign written consent.
- No active infection in the month before the device placement.
- You should not have certain serious liver/kidney or brain complications right now (see screening questions).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a procedure called splenic artery embolization (blocking part of the blood supply to the spleen) to reduce belly fluid buildup in people with advanced liver disease. It may help if your ascites has not improved with standard treatments and you are not a candidate for TIPS.
This Phase 2 trial tests whether high-dose albumin can reduce “refractory ascites,” which is fluid buildup in the belly that doesn’t improve with the highest tolerated water pills (diuretics). If you have liver cirrhosis and need frequent drainage, this study may offer a new treatment option.
This trial tests whether removing infected fluid from the belly early helps people with cirrhosis and an infection called SBP. It may reduce the chance of complications and improve recovery.
This trial studies whether a procedure called TIPS (a stent placed in the liver to improve blood flow) can help people with advanced liver disease regain better liver function. It is for patients who have had complications like severe bleeding from the stomach or difficult-to-control fluid buildup (ascites).
This study tests a personalized nutrition plan for people with liver disease who are about to have a TIPS procedure. It aims to help prevent confusion or other mental changes after the procedure, which can be a side effect.
This study tests a new version of a device (VIATORR TIPS) that helps lower high blood pressure in the liver for people with cirrhosis. The device is placed to create a small channel that reroutes blood flow and reduces pressure.
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