Acalabrutinib with or without obinutuzumab for early CLL/SLL
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This Phase 2 trial studies whether acalabrutinib, and optionally adding obinutuzumab, can control early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It aims to see how well these treatments work and how safe they are in people who have not had prior treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 18 or older and have either biopsy-proven SLL or CLL confirmed by specific blood test patterns.
- You have not been treated yet for CLL/SLL before starting the study (certain supplements and non-CLL steroids usually don’t count).
- Your CLL/SLL diagnosis was made less than 24 months before you register.
- Your CLL risk test (CLL-IPI) must be completed within about 2 years and the results for all required factors must be available (including IGHV if it’s part of your test).
- You must have good general health and function (ECOG performance status 0–2) and be well enough that the study team thinks treatment can be safely monitored.
- If your CLL risk is high or very high, you must meet specific blood test minimums and liver/kidney/bleeding-related lab limits, and you must provide pregnancy/cancer-cell-related safety checks if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This Phase 2 study tests venetoclax plus obinutuzumab, and whether adding acalabrutinib (or not) improves outcomes for people with relapsed or refractory CLL/SLL. It aims to see which combination works best and is safe for patients whose leukemia has returned or not responded.
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