Weight-loss surgery plus lifestyle changes for fatty liver disease
Part of Digestive system clinical trials.
This trial studies whether vertical sleeve gastrectomy (a type of weight-loss surgery) plus lifestyle coaching works better than another planned approach to improve non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. It may help people reduce liver fat and inflammation, but you must be willing to follow study visits and possible random assignment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 30 and 70 years old.
- You have one of these: confirmed NASH on a liver test, or prediabetes/type 2 diabetes, with blood sugar not too high (A1c under 9%).
- Your BMI is between 35 and 60.
- Scans show liver fat on a baseline MRI, and you can safely get a liver biopsy.
- You can speak English and agree to follow the study schedule and complete a short “run-in” period.
- You have health insurance that won’t block obesity-related treatment or help manage surgery complications.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study tests whether bariatric surgery (either sleeve gastrectomy or Roux-en-Y gastric bypass) improves severe nonalcoholic steatohepatitis (NASH) with advanced liver scarring in people who are obese. You may also need liver biopsies to confirm your liver disease before and after treatment.
This Phase 2 study tests whether SNP-610 (or a placebo) can improve non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. It also checks safety by comparing outcomes between the two groups.
This study checks whether an MRI scan can measure liver health in people with suspected fatty liver disease that may have progressed to NASH. Everyone in the study is also scheduled for a standard liver biopsy, which is used to compare the scan results.
This trial looks at whether weight-loss (bariatric) surgery helps people with fatty liver disease, including “NASH,” and related liver scarring. If you have obesity and a confirmed liver fat diagnosis (and for NASH, biopsy-proven NASH with some fibrosis), the study may follow your outcomes after surgery.
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
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