MACI transplant for knee cartilage defects in ages 10 to 17
Part of Bones, joints & muscles clinical trials.
This Phase 3 study tests whether a cartilage repair transplant called MACI (a lab-made cartilage-like tissue) can improve symptoms in young people with knee cartilage damage. It compares a surgery approach chosen for each person, aiming to reduce pain and improve knee function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 10 to 17 years old and have knee cartilage damage causing symptoms (pain and/or trouble using the knee).
- Imaging shows a specific kind of cartilage defect (Grade III or IV) on the thigh-bone area (femoral condyles) and/or the knee’s groove (trochlea).
- The defect is large enough (at least 1.5 square centimeters) and is the right type for this treatment (certain bone-involved defects may qualify if bone graft isn’t needed).
- Your knee is stable: the main ligaments (ACL and PCL) must be intact and not overly loose; any needed ligament procedures must be done before screening.
- Your meniscus is mostly present: at least 50% of the functional meniscus must remain (meniscus treatment may be done if the surgeon can confirm enough will remain).
- You can sign consent (and follow study visits and rehab); you haven’t had other non-diagnostic knee surgery in the last 6 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a treatment called MACI for people with damaged cartilage in their ankle. It uses your own cells to grow new cartilage, which may help reduce pain and improve how you can use your ankle.
This trial tests a cartilage-repair procedure called ACI for people whose knee cartilage injury has not improved after at least 6 months of prior treatment. If you qualify, it may help your cartilage heal and reduce symptoms.
This trial compares two surgical approaches to repair large areas of damaged cartilage and the bone under it in the knee. It’s for people who still have symptoms despite non-surgical treatment, and it may help improve recovery and knee function.
This study follows adults who are already scheduled for ACI surgery (a procedure that uses your own cartilage cells to repair knee injuries). It measures how well the knee works after surgery.
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