MACI for ankle cartilage defects in adults
Part of Bones, joints & muscles, Skin clinical trials.
This trial tests a treatment called MACI for people with damaged cartilage in their ankle. It uses your own cells to grow new cartilage, which may help reduce pain and improve how you can use your ankle.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 17 and 65 years old.
- You have at least one piece of damaged cartilage (grade 3 or 4) on the talus bone of your ankle, possibly with a cyst, and the damaged area is at least 1.2 cm².
- Your ankle pain and function scores are low (scores ≤ 50 on FAOS tests).
- You have not had any surgery on the target ankle (like a repair or replacement) in the last 6 months, except for a diagnostic scope.
- You are willing to avoid NSAIDs (like ibuprofen) for 12 weeks after treatment, and then use only over-the-counter pain relievers after that.
- Your blood tests show your hematocrit, white blood cell count, platelet count, creatinine, and INR are within normal ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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