MACI for ankle cartilage defects in adults
Part of Bones, joints & muscles, Skin clinical trials.
This trial tests a treatment called MACI for people with damaged cartilage in their ankle. It uses your own cells to grow new cartilage, which may help reduce pain and improve how you can use your ankle.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 17 and 65 years old.
- You have at least one piece of damaged cartilage (grade 3 or 4) on the talus bone of your ankle, possibly with a cyst, and the damaged area is at least 1.2 cm².
- Your ankle pain and function scores are low (scores ≤ 50 on FAOS tests).
- You have not had any surgery on the target ankle (like a repair or replacement) in the last 6 months, except for a diagnostic scope.
- You are willing to avoid NSAIDs (like ibuprofen) for 12 weeks after treatment, and then use only over-the-counter pain relievers after that.
- Your blood tests show your hematocrit, white blood cell count, platelet count, creatinine, and INR are within normal ranges.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 study tests whether a cartilage repair transplant called MACI (a lab-made cartilage-like tissue) can improve symptoms in young people with knee cartilage damage. It compares a surgery approach chosen for each person, aiming to reduce pain and improve knee function.
This trial tests a cartilage-repair procedure called ACI for people whose knee cartilage injury has not improved after at least 6 months of prior treatment. If you qualify, it may help your cartilage heal and reduce symptoms.
This trial compares two surgical approaches to repair large areas of damaged cartilage and the bone under it in the knee. It’s for people who still have symptoms despite non-surgical treatment, and it may help improve recovery and knee function.
This Phase 2 study tests CartiLife® to help repair a specific type of damaged knee cartilage. You may be considered if you have a moderate-sized cartilage defect in the knee and enough pain and function limits to need treatment.
This Phase 1 study tests whether an “AMIC” collagen-based treatment works better or safely than the standard microfracture procedure for a specific kind of hip cartilage injury. If you have ongoing hip pain from a cartilage defect (not arthritis), you may be able to join and receive one of these surgical treatments along with a study rehab plan.
This study follows adults who are already scheduled for ACI surgery (a procedure that uses your own cartilage cells to repair knee injuries). It measures how well the knee works after surgery.
Hear when a new Chondral Defect trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.