Brother or sister donor transplant using kidney and stem cells
Part of Blood & lymphatic, Immune system & allergy, Kidney & urinary clinical trials.
This study tests a combined approach for kidney transplant patients: standard living-donor kidney transplant plus an added “stem cell” component taken from the same sibling donor. It aims to improve transplant outcomes by trying to better control the immune response and reduce complications.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You need a living kidney transplant from an HLA-identical brother or sister at UCLA
- You must be able to consent, and you’ll live within about 3 hours of UCLA for the first 3–6 months
- Your blood counts, heart, lungs, and liver must meet study safety thresholds
- You must not have certain infections or immune-system test results (like HIV) and must be able to follow monitoring
- If you can become pregnant, you must have a negative pregnancy test and use reliable birth control for 12 months after transplant
- You must not have recent certain immune-suppressing medicines, immune therapy drugs, or recent major cancer activity
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combined transplant of blood-forming stem cells and a kidney from the same family member. It aims to help people with both advanced kidney failure and a blood cancer by potentially reducing the need for lifelong anti-rejection medicines.
This trial tests if a special stem cell treatment (using your own stem cells) can reset your immune system so you can accept a kidney from a deceased donor, even if you have very high antibody levels that make it hard to find a match. It's for people who have been waiting a long time and haven't had a transplant offer.
This study is testing a new way to help the body accept a kidney transplant without needing lifelong anti-rejection drugs. It involves transplanting a small piece of the donor's thymus (a gland that helps the immune system) along with the kidney, to train the body to see the new kidney as part of itself.
This Phase 1 study tests a treatment plan given after a kidney transplant to help the immune system stay calm and reduce the risk of rejection. Participants must have a well-functioning kidney transplant from a closely matched living donor and meet health and safety requirements.
This trial tests a way to help your body accept your liver transplant without needing lifelong anti-rejection drugs. It uses your living donor's stem cells to train your immune system to not attack the new liver.
This study tries to use a stem cell transplant from your original kidney donor to help your body accept the kidney without needing lifelong anti-rejection drugs. You must have a perfectly matched sibling donor who is still available.
Hear when a new Renal Transplant Rejection trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.