Extra chemotherapy around surgery for high-risk soft-tissue sarcoma
Treatments studied
Part of Cancer clinical trials.
This trial tests whether giving stronger chemotherapy before and/or after surgery helps people with high-risk, resectable soft-tissue sarcoma. It aims to lower the chance the cancer comes back by improving treatment around the time of the operation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed soft-tissue sarcoma diagnosis from a recognized French pathology network
- Your tumor is a grade 2 or 3 (how aggressive it looks under the microscope)
- Your cancer has not spread to distant organs and can be fully removed by surgery
- You have not had prior treatment for this sarcoma before starting the study
- You must be an adult (18+) with a life expectancy of at least 3 months and be well enough to do daily activities (ECOG 0–1)
- You need a measurable tumor spot on scan (meeting specific size rules), and you must be able to provide an archived tumor sample
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study looks at stored tumor tissue (or takes a new biopsy) to measure specific tumor markers. Researchers want to see whether these markers match how well chemotherapy works before surgery for soft-tissue sarcoma.
This trial tests whether giving chemotherapy both before and after surgery helps people with high-risk soft tissue sarcoma live longer and prevents the cancer from coming back. It aims to see if this treatment plan is more effective than surgery alone.
This trial tests a step-by-step (sequential) chemotherapy plan given before surgery for adults with specific types of soft tissue sarcoma. The goal is to shrink or control the tumor before the operation and see how well this approach works and is tolerated.
This trial tests combining anlotinib (a targeted therapy), doxorubicin (chemotherapy), and radiation given before surgery to shrink high-grade soft tissue sarcomas. The goal is to make the tumor easier to remove and improve outcomes.
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
This trial tests a combination of immunotherapy (atezolizumab), chemotherapy (doxorubicin), and radiation before and after surgery for people with high-risk soft tissue sarcoma in the arm, leg, or trunk. The goal is to see if this approach can improve outcomes.
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