De-intensified radiation after surgery for HPV throat cancer
Part of Cancer clinical trials.
This trial studies a lower-intensity (less aggressive) course of radiation therapy after curative surgery for HPV-related tonsil or base-of-tongue cancer. The goal is to see if patients can still be treated successfully while reducing side effects from radiation.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed squamous cell cancer in the tonsil or base of tongue, or an unknown primary, plus an HPV signal in the neck lymph node (p16-positive)
- Your tumor is HPV-associated (for example, p16 is strongly positive, or HPV tests like in-situ hybridization or PCR are positive)
- You are planning curative-intent surgery, and the surgeon expects clear margins (no cancer at the edge of tissue)
- Your cancer has not spread to distant sites (M0) and the tumor/nodes are early (T0–T2 and N0–N1)
- You meet general health/lab requirements (including blood counts and normal-ish liver/kidney tests) and can do normal daily activities (ECOG 0–1)
- You are 18+ and can sign consent; you also must not have had head and neck cancer in the last 5 years or prior head and neck radiation
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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