Psilocybin study for depression in mild memory or early Alzheimer’s
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This early-phase study tests whether psilocybin (a psychedelic substance) can help with depression in people who have mild memory problems or early Alzheimer’s. The trial also closely monitors safety, thinking changes, mood, and blood pressure before and after dosing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have mild cognitive impairment or early Alzheimer’s—either by clinical diagnosis or by memory test results (including CDR Memory > 0.5).
- Your thinking test scores must be within range (Mini-Mental State Exam over 18, and Montreal Cognitive Assessment under 26).
- You have depression symptoms at least mildly to moderately (based on a depression rating like CSDD or GDS-Short Form).
- You must have a close friend or family member who can act as an informant/community observer during study visits.
- You must be able to take part safely with your current medicines and have stable antidepressant regimens (SSRI/SNRI and/or bupropion) for the required time.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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