Testing propranolol vs ivabradine for POTS symptoms
Part of Brain & nervous system clinical trials.
This study compares two heart-rate medicines—propranolol and ivabradine—to see which better improves symptoms in people with POTS. It uses a “crossover” design, meaning you may try one medicine and then switch to the other.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with postural tachycardia syndrome (POTS)
- You are age 18 to 60
- You can give informed consent and are able to follow study instructions
- Your resting heart rate while sitting is not below 70 beats per minute without heart-rate–lowering meds
- Your blood pressure while lying down is not below 90/60
- No major heart rhythm/heart structure problems, pacemaker/ICD, or known coronary heart disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
This trial tests whether pyridostigmine helps people with postural tachycardia syndrome (POTS), which causes heart rate to rise when you stand up and can lead to unpleasant symptoms. You would be screened based on your tilt-table heart-rate response and your standing-related symptoms.
This study looks at whether adding salt helps improve POTS symptoms, especially the fast heart rate that happens when you stand. You’d be screened carefully to make sure your symptoms fit POTS and that other causes of fast heart rate are unlikely.
This trial tests a new medication (mirabegron) to help people with POTS (postural orthostatic tachycardia syndrome)—a condition where your heart races and you feel dizzy when standing up. The drug works by activating a specific nerve pathway to help control your heart rate and blood pressure.
Hear when a new Postural Tachycardia Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.