Pyridostigmine trial for postural tachycardia syndrome symptoms
Treatments studied
Part of Brain & nervous system clinical trials.
This trial tests whether pyridostigmine helps people with postural tachycardia syndrome (POTS), which causes heart rate to rise when you stand up and can lead to unpleasant symptoms. You would be screened based on your tilt-table heart-rate response and your standing-related symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with POTS using a tilt test (heart rate rises by at least 30 beats per minute within 5 minutes of standing/tilting)
- Your POTS symptoms happen when you stand up, such as lightheadedness, weakness, blurred vision, nausea, palpitations, or brain fog
- You are not pregnant and not breastfeeding
- You do not have thyroid problems (not uncontrolled hypothyroidism or hyperthyroidism)
- You have not had recent pyridostigmine treatment for POTS (none in the past month)
- You are able to participate safely without major other organ-system problems or heart artery disease, and you’re not on medicines that could interfere with the testing
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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Other trials that look related to this one.
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
This trial tests whether an ultrasound-guided nerve block in the neck (stellate ganglion block) can help people with POTS (a condition causing fast heart rate when standing) feel better. You would receive the injection and return for follow-up visits.
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
This study compares two heart-rate medicines—propranolol and ivabradine—to see which better improves symptoms in people with POTS. It uses a “crossover” design, meaning you may try one medicine and then switch to the other.
This Phase 2 study tests whether the medicines droxidopa and pyridostigmine can improve symptoms of orthostatic hypotension, which is low blood pressure when you stand up. It is designed for people whose low blood pressure is caused by problems with the nerves that control blood pressure.
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