Clinical trials
Postural Tachycardia Syndrome clinical trials
Below are recruiting postural tachycardia syndrome clinical trials, each written for real people, not researchers. We’re tracking 27 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05107635Recruiting
Registry for people treated with AtriCure for IST or POTS
This registry collects information from people who are getting—or already had—treatment for IST or POTS using an AtriCure device. It helps researchers better understand outcomes and safety in real-world care.
Loma Linda, CaliforniaAges 18–100 - NCT04271878Recruiting
Test breathing and blood-pressure response in POTS patients
This study measures how breathing patterns and heart rate/blood pressure change when you move from lying to standing in people with POTS. It may help researchers understand symptoms better and improve ways to manage them.
Calgary, AlbertaAges 18–60 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT05212129Recruiting
Stimulation of the ear nerve to help gut symptoms
This study tests whether stimulating a nerve in the ear (called auricular vagal nerve stimulation) can improve upper gut symptoms in teens who may have hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobile spectrum disorder (HSD). It also checks whether this treatment helps nerves that control the body (autonomic nervous system) and how well the gut moves.
Milwaukee, WisconsinAges 10–18 - NCT05375968RecruitingPhase 2
Test blood-flow changes in POTS after meals
This Phase 2 study looks at how blood pools in the belly veins when you stand or eat, in people with POTS (postural tachycardia syndrome). The goal is to understand what’s driving symptoms like feeling nearly faint and whether this helps guide better care.
Nashville, TennesseeAges 18–50 - NCT05554107Recruiting
Physical activity study for POTS symptoms
This study looks at how physical activity affects symptoms in people with POTS (a condition where heart rate rises when standing). If you have POTS, you may be asked to participate and help the researchers understand whether exercise changes how you feel.
MalmöAges 18 years+ - NCT06292104Recruiting
Understanding POTS: A study on heart rate and standing
This study looks at how the body controls heart rate and blood flow in people with POTS (a condition that causes dizziness and a fast heart rate upon standing). It helps researchers understand POTS better by comparing patients with healthy volunteers.
Dallas, TexasAges 14 years+ - NCT06936319Recruiting
Body movements for POTS symptom control
This study tests simple body movements (like squeezing your legs or squatting) to see if they help control POTS symptoms. It may offer a non-drug way to manage dizziness and fast heart rate when standing.
Innsbruck, TyrolAges 18–80 - NCT07189936RecruitingPhase 2
Testing 2-HOBA for Immune Issues in Long COVID with POTS
This trial tests if a medication called 2-HOBA can help with ongoing immune system issues in people with Long COVID who also have POTS. It aims to reduce fatigue and other symptoms by calming overactive immune responses.
Nashville, TennesseeAges 18 years+ - NCT07196397Recruiting
Polish Registry of Heart Nerve Procedures
This registry tracks people who have had or plan to have a procedure that changes the nerves controlling heart rate, such as cardioneuroablation. It aims to better understand and treat conditions like inappropriate tachycardia, POTS, and fainting spells.
RzeszówAges 18 years+ - NCT00409435RecruitingPhase 2
Pyridostigmine trial for postural tachycardia syndrome symptoms
This trial tests whether pyridostigmine helps people with postural tachycardia syndrome (POTS), which causes heart rate to rise when you stand up and can lead to unpleasant symptoms. You would be screened based on your tilt-table heart-rate response and your standing-related symptoms.
Rochester, MinnesotaAges 15–55 - NCT02725060Enrolling by invitation
Study of autoimmune changes in postural tachycardia syndrome
This trial studies whether an autoimmune (immune system–related) process is involved in postural tachycardia syndrome (POTS), a condition where your heart rate rises when you stand. The study may help researchers understand what causes POTS and how it could be treated or monitored.
Oklahoma City, OklahomaAges 18–50 - NCT04310644Recruiting
Study of nerve and connective-tissue symptoms in EDS and autonomic issues
This study collects information about how the body’s automatic nerves (autonomic nerves) affect symptoms like fast heart rate on standing, fatigue, and related conditions in people with Ehlers-Danlos syndrome. It also enrolls healthy volunteers to compare results, which may help doctors understand these conditions better and improve care.
Aachen, North Rhine-WestphaliaAges 18–80 - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT04186286RecruitingPhase 2
Testing propranolol vs ivabradine for POTS symptoms
This study compares two heart-rate medicines—propranolol and ivabradine—to see which better improves symptoms in people with POTS. It uses a “crossover” design, meaning you may try one medicine and then switch to the other.
Calgary, AlbertaAges 18–60 - NCT05618054Recruiting
Explaining nerve signals in teens with POTS
This study looks at how a specific brain–vagus nerve connection works in people with POTS and tries to understand what happens over time. It may help researchers better explain symptoms and other health problems that can occur with POTS.
Richmond, VirginiaAges 12–21 - NCT02673996Recruiting
Study of POTS body chemical signals and blood pressure control
This trial studies people with POTS (a condition where heart rate rises when you stand) and compares them with people without POTS. It tests body “adrenergic” (stress-chemistry) signals and how the body handles posture, which may help researchers find better ways to manage POTS.
Calgary, AlbertaAges 18–60 - NCT05633693Recruiting
Exercises to help children with fainting and blood-pressure drops
This study tests whether teaching special standing/balance movements can reduce fainting episodes in children who have recurring vasovagal fainting or certain forms of POTS. It may help your child feel more stable when standing and improve symptoms, while researchers measure balance and “counterpressure” responses during the tests.
Burnaby, British ColumbiaAges 6–18 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+ - NCT04881318Recruiting
Compression garments for POTS symptoms at home
This study tests whether wearing waist-high compression garments in everyday life can reduce symptoms for people with POTS. You’ll take part over a 4-day period and compare different days with a washout period in between.
Calgary, AlbertaAges 18–60 - NCT05555771Recruiting
Kids with fainting episodes after arriving at the emergency room
This study looks at children and teens (ages 6–18) who recently fainted but are now back to normal, using a survey. It aims to better understand fainting episodes that happen before the emergency visit and how to evaluate them safely.
Vancouver, British ColumbiaAges 6–18 - NCT05914649Recruiting
Testing long COVID and POTS brain fog symptoms
This study tests how different long-COVID and POTS-related symptoms—especially “brain fog”—show up and improve. It may help researchers better measure symptoms so future treatments can be targeted more effectively.
Calgary, AlbertaAges 18–60 - NCT05924646Recruiting
Testing salt to treat POTS symptoms
This study looks at whether adding salt helps improve POTS symptoms, especially the fast heart rate that happens when you stand. You’d be screened carefully to make sure your symptoms fit POTS and that other causes of fast heart rate are unlikely.
Calgary, AlbertaAges 18–60 - NCT06616363Recruiting
Brain and nerve connection in POTS and after infection
This study looks at why some people develop POTS (a condition that causes a fast heart rate and dizziness when standing) and if it's linked to how the brain and vagus nerve work together. It also includes people recovering from a serious infection and healthy volunteers for comparison.
Richmond, VirginiaAges 12–21
Hear when a new Postural Tachycardia Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for postural tachycardia syndrome?
- Yes. Clin2 currently lists 27 recruiting postural tachycardia syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a postural tachycardia syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a postural tachycardia syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.