Total marrow radiation using a targeted intensity plan before transplant
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 2 study tests a more precise type of whole bone-marrow radiation before a stem cell transplant. It may help patients with certain high-risk blood cancers by preparing the body for transplant more safely and effectively.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old.
- You have a planned stem cell transplant using a related half-match (haploidentical) donor or an unrelated donor with an allowed level of mismatch.
- Your diagnosis is one of the study types (such as relapsed/refractory acute leukemia, certain poor-risk AML or ALL in first remission, specific MDS situations, or mixed lineage/biphenotypic leukemia).
- Your heart, liver, and lung tests meet required thresholds (for example, heart pumping ≥40%, liver tests not too high, and lung function above the minimum).
- You must be able to sign informed consent.
- You should not have had more than 20% of the bone-marrow radiation areas previously, and you should not have major health limitations (like very weak heart function or very poor lung function).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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