Brain-focused ultrasound for opioid addiction-related substance use
Part of Mental health clinical trials.
This trial studies Exablate, a non-surgical brain treatment that aims to change activity in a specific brain area involved in cravings and substance use. It is meant for people in structured opioid or substance use treatment who are currently abstaining from opioids and other illicit drugs.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re age 18–60 (and if you can get pregnant, you must not be pregnant)
- You meet diagnostic criteria for opioid use disorder and/or another substance use disorder for at least 2 years
- You’re in a COAT-style treatment program (or a similar program the team knows) and, if you take medication for opioid/alcohol use, your dose has been stable for 7 days
- You’ve been off opioids and other illegal drugs (except cannabis) and a urine test supports that
- Your brain MRI shows the treatment target is visible, and you can report sensations during the procedure
- You can sit still for about 2–3 hours and you understand and sign the consent form
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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