Left atrial appendage closure vs blood thinners after brain bleed
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial compares a procedure that blocks a heart blood-choke point (the left atrial appendage) versus taking blood thinners by mouth. It is for people with atrial fibrillation who have had a brain bleed and may be safer avoiding long-term blood thinners.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You can sign consent and are at least 18 years old
- You have atrial fibrillation (short, ongoing, or long-term), and your stroke-risk score is at least 2
- Your brain (intracranial) bleeding happened more than 6 weeks ago
- Your heart scan shows the left atrial appendage shape is suitable for the closure device
- You do NOT have a blood clot in the left atrium or left atrial appendage on imaging
- You are not dealing with major issues like severe liver failure, serious infection, pregnancy, or very limited function
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests if closing the left atrial appendage with a special stitch during planned heart surgery can help prevent strokes in people with atrial fibrillation. If you already need heart surgery, this extra step may reduce your future stroke risk.
This study tests which blood-thinner approach works best after a procedure to close a small heart pouch (left atrial appendage) with a Watchman device. It aims to prevent strokes while reducing bleeding risks.
This study compares two approaches after a left atrial appendage closure (LAAC) procedure: taking no blood thinner versus taking just one antiplatelet medication. It aims to see which option is safer for people with atrial fibrillation who are at risk for bleeding.
This trial tests a procedure to close off a small pouch in the heart called the left atrial appendage, which is a common source of blood clots in people with atrial fibrillation. The goal is to lower your stroke risk without needing to take blood thinners long-term.
This study is for people who had a stroke despite taking blood thinners for atrial fibrillation. It tests if adding a procedure to close the left atrial appendage (a small pouch in the heart) to your blood thinner is better than just taking the blood thinner alone to prevent another stroke.
This study compares two ways to prevent stroke in people with persistent or long-standing atrial fibrillation (AF): taking a blood thinner (NOAC) or having a minimally invasive procedure to clip off the left atrial appendage (LAA). The goal is to see which approach works better at preventing stroke without causing major bleeding.
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