Testing early oral cyclosporine and eltrombopag for severe anemia
Treatments studied
Part of Blood & lymphatic, Immune system & allergy clinical trials.
This Phase 2 study tests whether starting two oral medicines early—cyclosporine and eltrombopag—can improve severe aplastic anemia in people who have not had prior treatment for it. It may help your blood counts recover without needing stronger or earlier treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are age 3 or older and weigh more than 12 kg
- You have severe aplastic anemia with low bone marrow activity (under 30%) plus very low blood cell counts
- Your blood tests show at least two problems such as very low neutrophils, very low platelets, or low reticulocytes
- You have not previously taken key treatments like ATG, cyclosporine, alemtuzumab, high-dose cyclophosphamide, or eltrombopag
- Recent liver and kidney labs are not too abnormal (liver enzymes/bilirubin not more than 2.5x/1.5x high limits; kidney filtering rate at least 40)
- You can safely take the medicines (no major heart disease, major infections not controlled, and you can swallow and join study visits by phone/video)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a lower dose of the chemotherapy drug cyclophosphamide combined with standard immune-suppressing medicines for people with newly diagnosed severe aplastic anemia. The goal is to see if this approach works as well as the usual treatment but with fewer side effects.
This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
This study looks at how well a standard combination of two medicines, cyclosporine and eltrombopag, works for people newly diagnosed with aplastic anemia (a condition where the bone marrow doesn't make enough blood cells). It aims to see if this treatment helps improve blood counts and overall outcomes.
This trial tests a combination of drugs to help your bone marrow make more blood cells if you have aplastic anemia and cannot have a stem cell transplant or standard immune therapy. It might improve blood counts and reduce the need for transfusions.
This trial compares two standard treatments for severe aplastic anemia (a condition where the bone marrow stops making enough blood cells). One treatment is a stem cell transplant from a donor, and the other is a drug therapy that suppresses the immune system. The goal is to see which works better as a first treatment.
This trial tests if sirolimus (an immune-suppressing drug) works better than current treatments for aplastic anemia patients who did not improve or had side effects from cyclosporin. It aims to find a new option to help your body make more blood cells.
Hear when a new Severe Aplastic Anemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.