Comparing two first-line treatments for severe aplastic anemia
Part of Blood & lymphatic clinical trials.
This trial compares two standard treatments for severe aplastic anemia (a condition where the bone marrow stops making enough blood cells). One treatment is a stem cell transplant from a donor, and the other is a drug therapy that suppresses the immune system. The goal is to see which works better as a first treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with severe aplastic anemia, including very severe forms or hepatitis-related cases.
- You are between 14 and 70 years old.
- You do not have a matched related donor for a stem cell transplant.
- You are not infected with HIV, hepatitis B, or hepatitis C.
- You have no medical conditions that would make transplant or immune therapy unsafe.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new way of using a mix of donor stem cells (from a half-matched family member and a cord blood unit) to treat aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if this transplant approach is safe and helps rebuild healthy blood cells.
This study tests a new combination of drugs to prepare older patients (40–60 years old) with severe aplastic anemia for a stem cell transplant from a half-matched donor. The goal is to make the transplant safer and more effective for this age group.
This Phase 1 trial tests a “lower-intensity” chemotherapy plan followed by a stem cell transplant from a related half-match donor for severe aplastic anemia that has returned or did not respond to prior medicines. It aims to see if this approach is safe and works well enough to help your blood counts recover.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
This trial tests whether giving children with aplastic anemia a transplant using a matched unrelated donor (a bone marrow donor who is not a family member) can help treat their condition. It aims to see if this approach is effective and safe for children who qualify.
This Phase 2 study tests a bone marrow transplant from a closely matched related donor, plus medicine after the transplant to help prevent immune complications. It may be an option if you have severe aplastic anemia and meet specific health and lab requirements.
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