Half-matched transplant vs. immune therapy for severe aplastic anemia
Part of Blood & lymphatic clinical trials.
This trial compares two first treatments for severe aplastic anemia: a half-matched (haploidentical) stem cell transplant versus immune-suppressing medicine. It is for people aged 14–70 who do not have a fully matched sibling donor.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 14 and 70 years old.
- You have been diagnosed with severe aplastic anemia (SAA), including very severe or hepatitis-related forms.
- You do not have a brother or sister who is a perfect tissue match for a stem cell transplant.
- You are free of HIV, hepatitis B, and hepatitis C infections.
- You have no other medical condition that would make a stem cell transplant or immune-suppressing therapy too risky.
- You are willing to sign a consent form (or have a family member or guardian do it for you).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new way of using a mix of donor stem cells (from a half-matched family member and a cord blood unit) to treat aplastic anemia, a condition where the bone marrow stops making enough blood cells. The goal is to see if this transplant approach is safe and helps rebuild healthy blood cells.
This study tests a new combination of drugs to prepare older patients (40–60 years old) with severe aplastic anemia for a stem cell transplant from a half-matched donor. The goal is to make the transplant safer and more effective for this age group.
This trial tests a “half-matched” stem cell transplant for children and teens with severe aplastic anemia when a fully matched donor isn’t available. It may help rebuild blood-making cells after prior treatments did not work well enough.
This Phase 1 trial tests a “lower-intensity” chemotherapy plan followed by a stem cell transplant from a related half-match donor for severe aplastic anemia that has returned or did not respond to prior medicines. It aims to see if this approach is safe and works well enough to help your blood counts recover.
This trial tests whether an early bone marrow transplant from a half-matched family member or an unrelated donor can help people with severe aplastic anemia. It aims to restore the body's ability to make healthy blood cells.
This trial tests a stem cell transplant option for children or young adults with severe aplastic anemia that did not respond to prior immune-suppressing treatment. It uses a “half-matched” donor and gives post-transplant cyclophosphamide to help the donor cells work and reduce certain immune reactions.
Hear when a new Aplastic Anaemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.