Hormone treatment to study thinking in Down syndrome
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Mental health clinical trials.
This trial studies whether a GnRH hormone treatment can improve thinking and memory in people with Down syndrome. It also checks safety and whether the treatment affects brain-related changes seen on MRI.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have a confirmed diagnosis of Down syndrome (trisomy 21)
- You can understand and follow the study steps (has verbal expression to participate)
- You agree to reliable, non-hormonal birth control for the whole study (for people who can get pregnant and their partners)
- You are not currently dealing with an acute illness that would require hospitalization
- You are not taking certain medicines that affect hormones (or related brain medicines), and you can be checked/confirmed
- You can safely do MRI scans (no metal/pacemaker and you agree to be informed only about allowed incidental findings)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at thinking skills (like memory and problem-solving) in adults with intellectual disabilities, including Down syndrome. You will complete some tests and interviews with a psychologist to understand how these skills work.
This study enrolls adults with Down syndrome to better understand how thinking and memory develop and change over time. It may help by building a “trial-ready” group and by measuring thinking in a careful, consistent way.
This study looks at how well a brain chemical system works in adults with Down syndrome as they age, including how it relates to Alzheimer’s-type brain changes and thinking skills. It uses brain scans and memory/thinking tests to see whether these measures can help track risk or changes over time.
This study tests whether a drug called memantine can help people with Down syndrome. It aims to see if it's safe and if it improves memory or thinking.
This study looks at how a healthy lifestyle program can improve brain health in adults with Down syndrome who are overweight or obese. You will attend a medical center three times over a year for tests, and you'll need a caregiver to support you.
This trial tests a brain stimulation approach aimed at affecting brain activity in people with Down syndrome. It may help researchers understand whether this kind of stimulation can improve certain brain or thinking-related outcomes.
Hear when a new Down Syndrome trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.