Spironolactone plus adrenal nerve treatment for adrenal overactivity
Part of Heart & circulation, Hormones & metabolism clinical trials.
This trial studies whether blocking part of the adrenal blood supply (“adrenal artery ablation”) along with spironolactone can improve hormone-driven high blood pressure caused by primary aldosteronism. It may help people who have confirmed adrenal overactivity and do not want surgery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have confirmed primary aldosteronism based on blood tests and an additional confirmatory test (saline or captopril test)
- Your aldosteronism cause should be one of these: idiopathic, bilateral adrenal enlargement, or one-sided overactivity confirmed by CT and adrenal vein blood testing
- You have a diagnosis such as aldosteronoma or one-sided adrenal overgrowth but you are not choosing surgery
- You must be able to sign informed consent and agree to participate
- You cannot have aldosterone cancer
- You must not have major safety issues like severe kidney/liver disease, high potassium, serious heart problems, active infections, or pregnancy
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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