Test treatment for primary aldosteronism and blood vessel function
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial studies whether a specific treatment (related to spironolactone/aldosterone support) can improve how well your blood vessels work in people with primary aldosteronism. It may help reduce blood pressure risk by improving blood vessel health.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 75 years old
- You have high blood pressure that meets specific readings over time (or on 24-hour monitoring)
- You were diagnosed with primary aldosteronism after stopping relevant drugs as required
- You have no major reasons you cannot take spironolactone-type treatment (as judged by the study team)
- You can choose drug treatment or a procedure called selective adrenal artery embolization, and the adrenal artery anatomy fits the plan
- Your kidneys and blood potassium are safe for the study (kidney filtering is not too low, and potassium is not high)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study compares two treatments for primary aldosteronism (a condition causing high blood pressure due to an adrenal gland issue). One treatment is a minimally invasive procedure called superselective embolization, and the other is keyhole surgery. This trial aims to see which is better and safer for patients.
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This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.
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