Test of an EGFR-targeting drug for advanced solid cancers
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism, Women’s health & pregnancy clinical trials.
This Phase 1 study tests the safety of BCA101 (an EGFR-targeting treatment) alone or combined with pembrolizumab. It may help people with certain EGFR-driven advanced cancers, depending on the tumor type, prior treatments, and required biopsy testing.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Have advanced cancer that can be measured on recent scans and that a doctor can biopsy (get tissue) before and after starting treatment
- Be able and willing to do a pre-treatment biopsy and an on-treatment biopsy, and share stored tumor tissue if available
- Be in good enough overall health (performance status of 1 or less)
- Have the right cancer type for the specific study “cohort” (for example, head and neck, anal canal, lung, colorectal, or skin), based on past treatments and lab results
- Be able to meet tumor testing needs, such as PD-L1 testing on real biopsy tissue (not fine-needle aspirate) and, for some cancers, HPV testing
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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