Cell therapy given during pregnancy to repair spina bifida
Part of Brain & nervous system, Genetic & congenital clinical trials.
This trial studies a cell-based treatment given during fetal surgery to help repair myelomeningocele (spina bifida) before birth. It aims to improve outcomes for the baby by supporting “in utero” repair, but you must meet strict pregnancy and health criteria to be considered.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are at least 18 years old
- You are between 19 weeks 0 days and 25 weeks 6 days pregnant at enrollment
- Your baby has myelomeningocele with hindbrain herniation (confirmed by ultrasound and MRI at the study center)
- You are eligible for fetal surgery under the MOMS trial rules (this trial uses the same screen)
- Your blood test results are compatible: normal chromosome testing (karyotype), and certain infections are negative
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study compares two ways to correct spina bifida while the baby is still in the womb: an open operation (laparotomy) versus a minimally invasive endoscopic approach (percutaneous endoscopic). The goal is to see which approach leads to better outcomes for the baby and pregnancy.
This study tests whether a patch made from donated umbilical cord can help repair spina bifida in the womb using a minimally invasive fetoscopic approach. If successful, it may reduce the need for more invasive open fetal surgery.
This study tests whether a special type of electrical stimulation applied to the skin over the lower spine can help improve function in children and teenagers with spina bifida. It aims to see if this treatment can make daily activities easier.
This study examines spinal fluid from babies with spina bifida to better understand a related brain condition (Chiari II malformation). The information could help improve care for future babies with this condition.
This study looks at how parents make decisions about fetal surgery for spina bifida (myelomeningocele) and how they feel afterward. It aims to understand the emotional and psychological effects to better support families.
This trial tests a treatment called transcutaneous spinal cord stimulation (tSCS)—gentle electrical pulses applied to the skin over the spine—to help children with spina bifida walk better and manage bladder control. The study includes children ages 4–17 who can walk short distances with help or devices.
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