Placebo vs allergy medicine to prevent transfusion reactions
Part of Immune system & allergy clinical trials.
This trial tests whether an allergy medicine (chlorpheniramine) can prevent allergic reactions during blood transfusions. You might be placed in either the medicine group or a placebo (inactive pill) group to compare side effects and reaction rates.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old
- You have a blood disorder and need a blood product transfusion (red cells, platelets, or plasma)
- You can understand the study and sign consent
- You do not have a history of allergic diseases or frequent prior allergic transfusion reactions
- You have not taken steroid allergy medicines or allergy drugs within 24 hours before transfusion
- You have not had washed red blood cells, past bone marrow transplant, or certain serious heart or stroke-related problems
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a special treatment to lower high levels of anti-HLA antibodies before a stem cell transplant. The goal is to help the transplant succeed and reduce the risk of rejection.
This study tests whether giving an antihistamine (a common allergy medication) before heart surgery can prevent allergic-type reactions that sometimes happen during the surgery itself. The trial includes children with certain types of congenital heart disease (heart problems present from birth).
This study checks if a special treatment to reduce germs in red blood cells is safe for patients who may have developed antibodies from past transfusions. You will receive a small transfusion of these treated cells to see how your body reacts.
This trial looks at patients who received a drug or product to help with bleeding (hemostasis) during anesthesia. It aims to understand how these products are used and if they are safe.
This trial tests a new device called the ABTest Card that checks your blood type from a finger prick. It may help make blood transfusions safer and faster for people who need them.
This study is testing a new device that checks your blood type before a transfusion. It is designed for adults who need blood and for newborns who need routine blood tests.
Hear when a new Allergic Transfusion Reaction trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.