Spironolactone to test sleep hormone patterns in teen girls
Treatments studied
Part of Cancer, Genetic & congenital, Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This early-phase study tests whether spironolactone can “normalize” a key hormone timing pattern during sleep and wake cycles in mid-to-late pubertal girls who have high male-hormone levels. The goal is to learn how this medicine may affect hormone rhythms related to conditions like PCOS.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are a mid- to late-pubertal girl (about ages 10–17, with specific breast development stages)
- You have signs of hyperandrogenism (higher-than-expected free testosterone and/or unwanted excess hair growth)
- You are generally healthy for the study, except for the specific hormone-related issues being studied
- You will not get pregnant during the study and will use reliable non-hormone birth control
- You do not have pregnancy now and are not breastfeeding
- You can safely take spironolactone (no key kidney problems, high potassium, or conditions that make it unsafe)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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