Treatment
Spironolactone clinical trials
We’re tracking 25 recruiting studies that include Spironolactone, each written for real people, not researchers, below.
Recruiting studies
- NCT06678685RecruitingPhase 2/Phase 3
Spironolactone for children with NCOR gene changes and autism
This trial tests if spironolactone can help children with autism who have a certain genetic change (in the NCOR gene). The study will monitor improvement and safety over time.
Jinan, ShandongAges 3–10 - NCT07041281RecruitingPhase 2
Spironolactone to improve postpartum blood pressure after pregnancy hypertension
This study tests whether the medication spironolactone can help manage high blood pressure after delivery in people who had gestational hypertension or preeclampsia. It may help prevent long-term heart problems.
Boston, MassachusettsAges 18 years+ - NCT02901184RecruitingPhase 3
Spironolactone start study for heart failure with preserved pumping
This trial tests whether starting spironolactone helps people with heart failure symptoms when the heart pumps “preserved” (not severely reduced). Participants are assigned to start spironolactone or usual care so researchers can see if it improves outcomes.
Alexander City, AlabamaAges 50–99 - NCT04723862RecruitingEarly Phase 1
Spironolactone to test sleep hormone patterns in teen girls
This early-phase study tests whether spironolactone can “normalize” a key hormone timing pattern during sleep and wake cycles in mid-to-late pubertal girls who have high male-hormone levels. The goal is to learn how this medicine may affect hormone rhythms related to conditions like PCOS.
Charlottesville, VirginiaAges 10–17 - NCT05092984RecruitingPhase 3
Spironolactone for rheumatoid arthritis with active symptoms
This trial tests whether spironolactone can reduce symptoms and inflammation in people with rheumatoid arthritis that is still active despite standard arthritis medicines. You may be able to join if your rheumatoid arthritis remains active and your current treatment plan has been stable for at least several months.
Strasbourg, AlsaceAges 18 years+ - NCT05807139RecruitingPhase 1
Spironolactone for alcohol use disorder
This Phase 1 study tests whether spironolactone (a medicine that affects salt and hormone balance) is safe and potentially helpful in people with alcohol use disorder. You may be eligible if you are currently drinking heavily, have low alcohol withdrawal symptoms, and meet several lab and medication safety rules.
Baltimore, MarylandAges 21–99 - NCT06523465RecruitingPhase 4
Statin plus amlodipine for primary aldosteronism
This trial tests whether combining a statin (usually for cholesterol) with amlodipine (a blood pressure medication) can better treat primary aldosteronism, a hormonal condition that causes high blood pressure. If you have this condition, this study may offer a new way to manage it.
Chongqing, Chongqing MunicipalityAges 18–70 - NCT07137364Recruiting
Testing spironolactone with blood pressure drugs for PA
This trial looks at whether adding spironolactone to your current blood pressure medicines works better for people with primary aldosteronism (a condition where your adrenal glands make too much aldosterone, raising blood pressure). You may qualify if you have this form of high blood pressure but have declined surgery or don't have an adenoma.
Chongqing, Chongqing MunicipalityAges 30–65 - NCT07223502RecruitingPhase 3
Comparing two treatments for high blood pressure and kidney disease
This trial tests if a new treatment combination (finerenone plus a water pill) works better than a standard fixed-dose combination for people with both high blood pressure and chronic kidney disease. It aims to find which option provides more clinical benefit.
Vienna, VirginiaAges 18 years+ - NCT07304817RecruitingPhase 2
Comparing two heart and kidney medicines in heart failure
This study tests if a new medicine (vicadrostat) works differently than an older one (spironolactone) in people with heart failure or heart disease and reduced kidney function. It aims to understand how they affect proteins in the blood and kidney blood flow.
Groningen, Provincie GroningenAges 18 years+ - NCT07328230Recruiting
New procedure vs standard pill for adrenal-related high blood pressure
This study tests if a new procedure (blocking tiny adrenal arteries) works as well as a standard pill (spironolactone) for lowering high blood pressure caused by too much aldosterone from both adrenal glands. It is designed for people whose high blood pressure is due to idiopathic hyperaldosteronism.
Beijing, Beijing MunicipalityAges 15–60 - NCT01712620RecruitingPhase 2
Spironolactone for pulmonary arterial hypertension in stable patients
This trial studies whether spironolactone can improve pulmonary arterial hypertension, a disease that makes the blood vessels in the lungs work too hard. You may be eligible if your condition is confirmed by specific heart-lung pressure tests and your medication plan has been stable for at least 4 weeks.
Bethesda, MarylandAges 18–100 - NCT07415811Enrolling by invitation
Spironolactone for HIV-infected adults
This study tests the drug spironolactone, a medicine that helps your body balance fluids and potassium, in both HIV-positive and HIV-negative adults. The goal is to see how it affects a key protein complex in your cells. If you are HIV-positive, you need to have well-controlled HIV with undetectable virus levels and be on stable treatment.
São Paulo, São PauloAges 18–60 - NCT03984591Enrolling by invitationPhase 4
Compare spironolactone vs eplerenone for heart failure patients
This study uses Denmark’s heart failure registry to compare two common tablet medicines—spironolactone and eplerenone—for people with symptomatic systolic heart failure. It aims to see which one leads to better health outcomes over time.
CopenhagenAges Any age - NCT05754684RecruitingPhase 2
Immunotherapy with donor NK cells for relapsed neuroblastoma
This trial studies a “quadruple immunotherapy” treatment using donor immune cells (NK cells) to fight neuroblastoma that has come back or did not respond to prior therapy. It may help by boosting the body’s immune attack, but only certain children meet the safety and donor requirements.
Hong KongAges Up to 18 years - NCT03068910RecruitingEarly Phase 1
Study of hormone timing in teens with high androgens
This early study looks at how certain “male-type” hormones and brain signals (measured through hormone patterns during the day and night) work in adolescent girls with high androgen levels. It may help researchers better understand causes like PCOS and related hormone timing differences.
Charlottesville, VirginiaAges 10–17 - NCT03593317RecruitingPhase 2
Test medicine that blocks hormones for ARVD heart disease
This Phase 2 trial studies whether blocking certain heart/hormone signals can improve ARVD (a heart muscle condition). It also looks at safety by checking how well your kidneys and electrolytes tolerate these medicines.
AmiensAges 18 years+ - NCT04409431Recruiting
Spironolactone plus adrenal nerve treatment for adrenal overactivity
This trial studies whether blocking part of the adrenal blood supply (“adrenal artery ablation”) along with spironolactone can improve hormone-driven high blood pressure caused by primary aldosteronism. It may help people who have confirmed adrenal overactivity and do not want surgery.
Chongqing, Chongqing MunicipalityAges 30–60 - NCT05501080Recruiting
Testing a hormone treatment to improve heart changes in PA
This trial tests whether a treatment called SAAE can improve “ventricular remodeling,” meaning changes in the heart muscle, in people with primary aldosteronism (PA). It may help the heart work more efficiently by targeting the cause of high aldosterone levels.
NanchangAges 18–60 - NCT05561361Recruiting
Test treatment for primary aldosteronism and blood vessel function
This trial studies whether a specific treatment (related to spironolactone/aldosterone support) can improve how well your blood vessels work in people with primary aldosteronism. It may help reduce blood pressure risk by improving blood vessel health.
NanchangAges 18–75 - NCT06457074RecruitingPhase 4
Finerenone for primary aldosteronism (FAIRY trial)
This trial tests a drug called finerenone for people with a specific cause of high blood pressure (primary aldosteronism). It aims to see if finerenone can help lower blood pressure and improve hormone levels better than current care.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07688928Recruiting
Finerenone vs spironolactone for high blood pressure from aldosteronism
This trial compares two medicines, finerenone and spironolactone, to see which works better and is safer for lowering blood pressure in people with primary aldosteronism. It may help you if you have high blood pressure caused by too much aldosterone.
DhakaAges 18 years+ - NCT07020104Recruiting
Salt and water in chronic kidney disease
This study looks at how salt builds up in the skin of people with chronic kidney disease. It involves different groups testing either sodium intake, sodium excretion, or water intake to see how these affect blood pressure and kidney function.
Amsterdam-Zuidoost, North HollandAges 18 years+ - NCT02378805Recruiting
Alport syndrome registry to help delay kidney failure
This is a registry that collects information from people with Alport syndrome to better understand the disease and how to delay kidney failure. It may help researchers learn which factors and treatments are most important over time.
Göttingen, Lower SaxonyAges Any age
What Spironolactone is being studied for
Conditions with recruiting Spironolactone studies.
Common questions
- Are there clinical trials studying Spironolactone?
- Yes. Clin2 currently lists 25 recruiting studies that include Spironolactone, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Spironolactone trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Spironolactone an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Spironolactone or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.