Study brain response to inflammation in depression
Part of Mental health clinical trials.
This early-stage study tests how your brain responds to an “inflammatory challenge” in people with major depressive disorder and in healthy volunteers. It may help researchers understand the immune-to-brain link in depression and guide future treatments.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18–65 years old
- If you join the depression group, you have moderate-to-severe symptoms (PHQ-9 ≥10 and/or MADRS ≥7)
- You are in overall good health, including a normal EKG and blood pressure/pulse/temperature on the day of testing
- You are not pregnant and can follow pregnancy-related safety rules
- You can safely have MRI scanning (no incompatible metal/implants and you can lie still for 60 minutes)
- You avoid certain medicines and immune-affecting treatments (for example steroid pills regularly, immune drugs like TNF blockers, and certain anti-inflammatories)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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