Comparing two new valve options for a failing replacement aortic valve
Part of Heart & circulation clinical trials.
This trial compares two types of replacement heart valves (balloon-expandable and self-expanding) for people whose prior surgical aortic valve is no longer working. It looks at which valve type offers better outcomes when placed through a catheter in the leg.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- Your surgical aortic valve is failing and needs replacement.
- You are eligible for a transfemoral TAVI procedure (a new valve placed through a catheter in the leg) with either the EVOLUT, SAPIEN, or MYVAL valve systems.
- You do not need another heart valve repair at the same time.
- You have not had a stroke or mini-stroke within the last month.
- You do not have a mechanical aortic valve or a blood clot in the main pumping chamber of your heart.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial compares two ways to replace a narrowed heart valve in people with a bicuspid aortic valve. If you're 50 or older and need a new valve, this study can help figure out which approach works best.
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
This trial compares two newer types of replacement heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) to see which one works better for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. If you join, you'll be randomly assigned to receive one of the two valves during your TAVI procedure.
This trial compares two different types of replacement heart valves for people whose previous surgical aortic valve has failed. Both valves are placed using a less invasive method (through a leg artery), and the study aims to see which option works better for this 'valve-in-valve' procedure.
This trial compares two different types of replacement heart valves (balloon-expandable vs. self-expanding) to see which works better for people with severe aortic stenosis. The goal is to find the best option for each patient.
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
Hear when a new Valve Heart Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.