Comparing two replacement heart valves for failed surgical aortic valves
Part of Heart & circulation clinical trials.
This trial compares two different types of replacement heart valves for people whose previous surgical aortic valve has failed. Both valves are placed using a less invasive method (through a leg artery), and the study aims to see which option works better for this 'valve-in-valve' procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a surgically placed aortic heart valve that is no longer working properly (it is either too narrow or leaking).
- Your doctor has said you are suitable for a less invasive valve replacement procedure through a vein in your leg.
- You are willing to give written consent to take part and attend follow-up visits.
- You do not have any of the conditions listed that would make the procedure unsafe (such as recent heart attack, active infection, severe kidney disease, or pregnancy).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new heart valve called DurAVR for people with severe aortic stenosis (a narrowed aortic valve) who need a valve replacement. It compares the new valve to standard valves to see if it is safe and works well.
This trial compares two types of replacement heart valves (balloon-expandable and self-expanding) for people whose prior surgical aortic valve is no longer working. It looks at which valve type offers better outcomes when placed through a catheter in the leg.
This trial compares two newer types of replacement heart valves (SAPIEN 3 Ultra Resilia and Evolut FX) to see which one works better for people with severe aortic stenosis, a condition where the heart's main valve becomes narrow. If you join, you'll be randomly assigned to receive one of the two valves during your TAVI procedure.
This trial compares two different types of replacement heart valves (balloon-expandable vs. self-expanding) to see which works better for people with severe aortic stenosis. The goal is to find the best option for each patient.
This trial tests a new heart valve called Hydra for people with severe aortic stenosis who need a valve replacement through a leg artery. It aims to see how well the valve works in real-world patients.
This trial compares two ways to treat a failing aortic valve that was replaced with a tissue valve during surgery: another surgical replacement or a less invasive catheter-based valve-in-valve procedure. It is for people with low to intermediate surgical risk who are between 18 and 75 years old.
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