Therapy with psilocybin for severe OCD symptoms
Part of Mental health clinical trials.
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a clinician-confirmed OCD diagnosis.
- Your OCD symptom severity must be high (Y-BOCS score 16 or higher).
- You must have tried at least one standard OCD treatment (medication and/or therapy) but it did not work well.
- You must be between 18 and 65 years old and able to attend all sessions and follow-ups.
- You must stop certain OCD medicines (selective serotonin inhibitors) long enough before starting (five drug “half-lives” plus 2 weeks).
- You must agree not to start new psychiatric treatments or take psychiatric meds or recreational drugs during the study (unless the study team says otherwise).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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