Pre-surgery proton radiation plus chemo for borderline pancreatic cancer
Treatments studied
Part of Cancer, Digestive system, Hormones & metabolism clinical trials.
This trial tests whether giving proton radiation and chemotherapy before surgery can shrink or control “borderline resectable” pancreatic cancer so it can be removed more effectively. It may help by improving treatment response while planning for surgery afterward.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have confirmed pancreatic cancer (from a biopsy or fluid test)
- Your cancer is considered “borderline resectable” and has not spread to distant organs
- No tumor growth into the stomach or duodenum (upper gut lining)
- Your blood counts and liver/kidney tests are within required safety ranges
- You are fit enough for treatment (adult age and good functional status) and can give consent
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving targeted radiation therapy first, followed by a combination chemotherapy (NALIRIFOX), is better than chemotherapy alone for people with pancreatic cancer that is borderline resectable. The goal is to see if the radiation helps shrink the tumor enough to make surgery possible.
This trial tests a combination of chemotherapy drugs (AG and FOLFIRINOX) with an immunotherapy drug (PD-L1 antibody) to shrink pancreatic tumors that are borderline resectable or locally advanced, making them removable by surgery. It's for people who haven't had any previous cancer treatment.
This trial tests proton radiation for people with pancreas cancer that cannot be fully removed by surgery (or who choose not to have surgery). It may help shrink or control the cancer using a treatment that aims to better target the tumor while limiting dose to nearby organs.
This trial tests whether adding the drug IBI343 to chemotherapy before surgery can help people with borderline resectable pancreatic cancer. It is for those whose tumors have a specific protein called CLDN18.2 and have not spread to other parts of the body.
This early trial studies whether adding targeted radiation during or around pancreatic surgery is safe and may improve outcomes for people with borderline resectable pancreatic cancer. It is mainly looking at feasibility and safety while treating close to the tumor but not spreading (no metastasis).
This trial tests a combination of four drugs (liposomal irinotecan, 5-fluorouracil, oxaliplatin, and adebrelimab) given with radiation therapy before surgery for pancreatic cancer that can be surgically removed or is borderline removable. The goal is to shrink the tumor and improve the chances of successful surgery.
Hear when a new Pancreatic cancer trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.