Vaccine plus pembrolizumab, with or without low-dose chemo
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This Phase 2 study tests whether a cancer vaccine called DPX-Survivac, along with pembrolizumab (an immune medicine), can help shrink diffuse large B-cell lymphoma (DLBCL) that has come back or not responded. It also looks at whether adding intermittent low-dose cyclophosphamide (a low-dose chemotherapy) improves results.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are an adult (18+) and can sign informed consent
- Your health/strength is fairly good (ECOG 0–1; ECOG 2 only if the study doctor approves)
- You have confirmed DLBCL and your cancer has progressed after at least two prior treatments that included an anthracycline and rituximab (or another CD20-targeted drug)
- You cannot (or did not get benefit from) stem cell transplant or CAR-T therapy
- You have at least one measurable tumor area on scans and can provide tumor biopsies before and during treatment
- You are generally healthy enough for study treatment (lab results acceptable) and are expected to live more than 3 months
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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