2-HOBA to improve “good cholesterol” function in FH
Part of Genetic & congenital, Hormones & metabolism clinical trials.
This Phase 2 trial tests whether 2-HOBA can improve how “good cholesterol” (HDL) works in people with familial hypercholesterolemia (FH). If HDL works better, it may help lower heart risk markers. You would need to meet several heart, health, and medication-related safety checks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have heterozygous familial hypercholesterolemia (FH), not another type of high cholesterol
- You did not have a heart attack or stroke in the past 6 months
- You have no unstable chest pain (unstable angina) and no angina symptoms in the past 3 months
- Your heart pumping function is not too weak (no NYHA class III/IV heart failure and LVEF is at least 30%)
- Your blood pressure is not dangerously high (SBP ≤ 180 and DBP ≤ 110)
- You are not pregnant and you do not have several other key exclusions (see screening questions)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 1 study tests a new treatment using tiny delivery particles (“exosomes”) to carry instructions (LDLR mRNA) that may help lower LDL (“bad”) cholesterol in people with homozygous familial hypercholesterolemia. The main goal is to see if it’s safe and learn how the treatment behaves in the body.
This study looks at how familial hypercholesterolemia (a genetic condition that causes high cholesterol) affects mothers and their newborns. It aims to learn more about cholesterol levels during pregnancy and the baby's first week of life.
This trial focuses on people with familial hypercholesterolemia (FH), an inherited condition that causes very high cholesterol. It aims to better understand and manage severe cholesterol problems that raise heart risk, especially in families.
This trial tests whether a natural compound called 2-HOBA can help women with lupus who also have mildly high blood pressure. It aims to improve blood vessel health and reduce inflammation.
This study tests a new oral drug called 2-HOBA (a natural compound found in curry) in people with early-stage Alzheimer's. The drug may help protect brain cells and possibly slow memory decline. Participants will take the drug daily for a period, and researchers will monitor changes in cognition and biomarkers.
This trial tests whether a dietary supplement called 2-HOBA can help people with high levels of lipoprotein(a), a type of fat in the blood linked to heart disease. You take the supplement daily for several weeks while following your doctor's diet advice.
Hear when a new Familial Hypercholesterolemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.