CAR-T for solid tumors with high GPC3 protein
Treatments studied
Part of Cancer, Digestive system clinical trials.
This early-phase trial tests a personalized CAR-T cell treatment for cancers that make a lot of a protein called GPC3. If you have advanced cancer that has already tried at least one standard treatment, and your tumor has enough GPC3, this study aims to see how well the treatment can shrink tumors and how safe it is.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You’re 18 or older with confirmed liver cancer (HCC) or another solid tumor
- Your cancer has gotten worse after at least one prior treatment, or you couldn’t tolerate it
- You can get a tumor biopsy before treatment to check whether your tumor has enough GPC3 (at least 25%)
- You must have at least one measurable tumor spot that can be tracked on scans
- Your health tests must be strong enough (blood counts, liver/kidney function, and oxygen level) for CAR-T treatment
- You likely must have cancer that cannot be cured with surgery, ablation, or transplant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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