Vyxeos plus gilteritinib for certain relapsed AML
Treatments studied
Part of Blood & lymphatic, Cancer clinical trials.
This Phase 1 trial studies whether combining Vyxeos (a chemotherapy) with gilteritinib (a targeted drug) can treat AML that has come back or hasn’t responded well, specifically AML with certain FLT3 mutations. If it works, it could improve chances of controlling the leukemia.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You sign an informed consent form and can follow all study visits and procedures.
- Your AML has an FLT3 mutation (either FLT3-ITD or FLT3-TKD, but not AML subtype M3) and it is in relapse or not responding after at least one prior AML treatment.
- Your FLT3 mutation result must be confirmed again at the time of relapse.
- Your heart pumping strength is adequate (LVEF 50% or higher) and your overall activity level is fairly good (ECOG 0–2).
- You can take pills as directed, and your organs (kidneys/liver) are strong enough for treatment.
- If you can become pregnant, you must use very effective birth control and have required pregnancy tests; if you are breastfeeding, you must stop.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two targeted drugs, SNDX-5613 and gilteritinib, for people whose AML has come back or hasn't responded to treatment. It is for those with an FLT3 gene mutation plus another specific genetic change like NPM1 or MLL. The study aims to see if this two-drug approach works better when used together.
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This trial tests a combination of two chemotherapy drugs, Vyxeos (liposomal daunorubicin and cytarabine) and clofarabine, in children and young adults whose acute myeloid leukemia (AML) has come back or hasn't responded to standard treatment. The goal is to see if this combination can help control the leukemia.
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